Finally, a prognosis model for osteosarcoma based 10 GPCRs was constructed, among them, GPR158, CCR4, DRD2, HCRTR2, HTR1A, and GPR3 with an HR < 1, while HTR1E, OPN3, GRM4, and GPR144 with an HR > 1. This evidence concerns the gene GRM4 and osteosarcoma.