CXCL8 and major depressive disorder: Interestingly, schizophrenia has been found to be associated with elevated maternal IL-8 blood concentrations during the second trimester of pregnancy, and anxiety-depression symptoms were related with lower IL-7 in the cord serum at birth (Al-Haddad et al., 2019; Ratnayake et al., 2013; Galera et al., 2021).