The ROC analysis with cortisone can discriminate 60% of subjects with low renin (AUC 0.6), although it has a low predictive value, which is similar to serum aldosterone per se; however, the combination of both variables with the SBP can discriminate 80% of the subjects with low renin, suggesting other causes of low renin associated with glucocorticoid-mediated MR activation, such as classical AME and NCAME syndrome, which consequently decrease PRA and could modify the aldosterone–renin ratio, generating a false positive. The gene discussed is REN; the disease is apparent mineralocorticoid excess.