GLP1R and type 2 diabetes mellitus: Additionally, GLP acts on receptors in the central nervous system and gastrointestinal tract, which delay gastric emptying, resulting in a reduction in appetite (increased satiety) and delayed glucose absorption.1 For those individuals who have insulin resistance (insensitivity) and/or are diagnosed with T2DM, GLP-1 receptor agonists are oral or injectable medications that mimic this natural hormone and may be recommended to help manage blood sugar in some patients.1,3