Importantly, from the DepMAP database, cumulative analysis of essentiality scores for all histone acetyltransferases (HATs) and histone deacetylases (HDACs) in AR-positive prostate cancer cell lines (namely VCaP and LNCaP) identified p300 as the most essential gene in these cell lines (Figure 1D). The gene discussed is AR; the disease is prostate carcinoma.