Consistent with our in vitro findings, immunohistochemistry (IHC) staining and western blotting of tumor xenografts five days post treatment confirmed significant downregulation of p300/CBP, AR, PSA, MYC, Ki67, CCND1, NKX3–1, CITED2, H3K27ac, and H2BK20ac (Figures 8D and S10B–C). This evidence concerns the gene EP300 and neoplasm.