In mCRPC, crucial oncogenic transcription factors, including the androgen receptor (AR), FOXA1, HOXB13, ERG, and MYC, recruit and collaborate with epigenetic coregulators at enhancer sites in cancer-specific complexes known as neo-enhanceosomes to create active chromatin environments that drive hyper-expression of oncogenic genes through looping interactions with promoters4–9. The gene discussed is AR; the disease is cancer.