Finally, significant differences were observed in P(FTD) and P(V D) based on their respective pathological markers: P(FTD) differed significantly between cases with and without TDP-43 pathology (p < 0.01) and tauopathy (p < 0.05), P(V D) varied between cases with and without old microinfarcts (p < 0.001) and arteriolosclerosis (p < 0.001) (Figs. 5e–h). Here, TARDBP is linked to tauopathy.