We identified heterozygous MYH10 variants in five pedigrees with CN3-oCCDDs: ENG_CKM (isolated familial CFEOM), ENG_ASW (syndromic sporadic CFEOM), ENG_YY (isolated sporadic MGJWS(+)ptosis), ENG_PJ (isolated sporadic MGJWS(+)ptosis), and ENG_CGO (isolated sporadic MGJWS(−)ptosis) (Supplementary Table 7, Supplementary Figure 9). This evidence concerns the gene MYH10 and congenital fibrosis of the extraocular muscles.