Separate MYH10 heterozygous missense or loss-of-function variants were recently associated with neurodevelopmental phenotypes, which included ptosis in 3 individuals, lateral rectus muscle weakness in 1 individual, and CN5/CN7 palsy in 1 individual.25,26 Additional MYH10 missense variants have been reported in probands with ptosis, coloboma, and craniofacial dysmorphisms (Scheidecker et al., personal communication). This evidence concerns the gene MYH10 and coloboma.