In addition, after infection with PEDV-CV777 strains, it was found that the secretion levels of transforming growth factor (TGF)-β and IFN-α were significantly higher in B cells from nursery piglets at 48 hpi (Figures 2C, D) and those of IL-4 significantly increased from nursery piglets at 24 hpi (Figure 2E). Here, IL4 is linked to infection.