Coudert et al. 43 showed that aggregation and phosphorylation of TDP-43 were induced in cells with a HTT repeat expansion and that mutant Huntingtin (HTT) co-localized with TDP-43, supporting that repeat expansions in HTT are a potential genetic risk factor for amyotrophic lateral sclerosis. The gene discussed is HTT; the disease is amyotrophic lateral sclerosis.