In recent murine cell culture experiments, G6P was found to be 377% higher in astrocytes from Lafora disease mice compared with controls.12 Also, evidence has been obtained that malin ubiquitinates and regulates the signalling protein P-Rex1, which promotes translocation of the GLUT4 glucose transporter to the cell membrane, and that malin deficiency results in increased glucose transport.49 Finally, in the current work we find that UDP(G) is 48% higher in Lafora disease patients versus controls. This evidence concerns the gene SLC2A4 and Lafora disease.