L. plantarum ZS62 downregulated the serum levels of IL-1β, IL-6, IL-12, TNF-α, and IFN-γ, and the relative mRNA and protein expression of IL-1β, IL-12, and TNF-α in colonic tissues of IBD mice, with upregulation of serum and relative mRNA and protein expression levels of IL-10 [107]. Here, TNF is linked to irritable bowel syndrome.