P2RX7 and Sepsis: In a sepsis model established using cerebrovascular endothelial cells, western blot and immunofluorescence analyses showed that P2X7R expression was significantly increased in endothelial cells, and the tight-junction proteins of endothelial cells were significantly defective; moreover, P2RX7 knockdown ameliorated leukocyte-endothelial cell adhesion in septic mice [19].