BCL2 and breast carcinoma: Their mode of action involves the direct or indirect regulation of anti-apoptotic (such as Bcl-2 and Bcl-x) and pro-apoptotic (such as Bcl-10 and Bax) proteins, leading to the expression of caspase-9, caspase-3, and caspase-7, key players in apoptosis to induce the apoptosis of breast cancer cells.