BCL2 and breast cancer: The copper complex [Cu (SBCM)2] developed by Jhi Biau Foo et al. induced cytochrome c release, which, in turn, activates Apaf-1 and procaspase-9 to form an “apoptosome,” thereby downregulating anti-apoptotic protein Bcl-2 in breast cancer cells, followed by a change in cell membrane permeability [58,59,60].