Treatment of tumor-bearing mice with P. frutescens seed polysaccharide (0.1, 0.3, and 0.5 mg for 10 days) significantly reduced the levels of lactate dehydrogenase, aldolase, and interleukin (IL)-10; increased the levels of IL-2 and tumor necrosis factor-alpha (TNF-α) in the serum of mice; and down-regulated the expression of the anti-apoptotic protein Bcl-2 and up-regulated the expression of the pro-apoptotic protein Bax (17). This evidence concerns the gene TNF and neoplasm.