Autophagy is a process that transfers waste products, cellular components, and large molecules to the lysosome for decomposition and ingestion.24 Autophagy disturbance is one of the etiologies of PD, leading to α-syn accumulation in the brain.79 Moreover, deleting essential genes involved in autophagy, such as autophagy-related gene-7 (ATG-7), can induce neurodegeneration similar to PD in mice.80 A recent study has shown that tricin, a natural flavonoid, can improve autophagy and ATG-7-dependent clearance of α-syn via an AMPK/mTOR pathway.81 Here, MTOR is linked to Parkinson disease.