To accomplish this, autophagosomes are formed to separate cytoplasmic components and carry them to lysosomes.83,84 In both PD patients and animal models, macroautophagy is stimulated by transcription factor EB (TFEB), which mediates lysosomal biogenesis and macroautophagy development due to increased α-syn levels.85,86 In the PD mice model, overexpression of α-syn causes macroautophagy dysfunction and increases dopaminergic neuron degeneration in SNpc and movement disorders. The gene discussed is TFEB; the disease is Parkinson disease.