Although specific investigations have raised doubts about the role of IFN-γ blockers due to worsened prognosis of severe COVID-19 patients by generating secondary infections in COVID-19 cases, INF-γ blockades could be the core of the treatment.184 Numerous studies have reported that several phytochemicals possess potent abilities to reduce or block IFN-γ activation pathways. The gene discussed is IFNG; the disease is COVID-19.