Nevertheless, it could be in line with human brain disorders when pathological conditions persevered for years.58 Bolmont and colleagues showed that an increase in the accumulation of these cells around the amyloid deposits, and the production of cytokines promoting neuronal death were found in AD pathogenesis.59 Therefore, it had been hypothesized that microglia dysfunction played a critical role in amyloid plaque deposition.39 TSPO structure provided insight and fundamental information regarding its function and interaction with several ligands.60 This evidence concerns the gene TSPO and brain disorder.