FOLH1 and cancer: [68Ga]/[177Lu]-PSMA-I&F (Figure 8) exhibited high PSMA-targeting efficiency and favorable pharmacokinetic properties, enabling high-contrast and sensitive detection for in vivo study of PSMA expression using preclinical PET/SPECT and optical imaging.153 In addition to the hybrid molecules targeting PSMA, various other molecules had been developed for imaging multiple cancer types.