An integrative transcriptomic analysis of post-mortem spinal cord samples from ALS and ALS/FTD patients revealed a down-regulation of the expression of several genes that were specifically ascribed to the oligodendrocyte cell type; in particular, a decrease in the expression of MOBP, involved in myelin compaction, was observed (Humphrey et al., 2023). Here, MOBP is linked to amyotrophic lateral sclerosis.