TARDBP and amyotrophic lateral sclerosis: Interestingly, mutant forms of ALS and FTD-linked TDP43 and C9orf72 were shown to trap HNRNPA2, likely compromising the transport of Mbp mRNA toward the myelin sheath (Buratti et al., 2005; DeJesus-Hernandez et al., 2011; Lorente Pons et al., 2020).