In particular, oligodendroglial TDP43 inclusions were specifically associated with mutations in several genes linked to ALS (e.g., angiogenin, C9orf72 and optineurin) or FTD (e.g., C9orf72, progranulin and sequestosome 1) (Seilhean et al., 2009; Kovacs et al., 2016). The gene discussed is OPTN; the disease is amyotrophic lateral sclerosis.