In support of this notion, loss of cells positive for oligodendrocyte transcription factor 2 (OLIG2) that was observed in the corpus callosum of a FTD mouse model lacking the gene encoding the lysosomal transmembrane protein 106B (TMEM106B), affected differentiated but not undifferentiated oligodendrocytes. Here, OLIG2 is linked to frontotemporal dementia.