Since ERBB4 expression is in part controlled by interacting with TDP43, it was postulated that the cytoplasmic delocalization of TDP43, typically observed in ALS and FTD, could affect ERBB4 mRNA transport and/or translation and hence impair oligodendrocyte maturation (Schwenk et al., 2016). The gene discussed is TARDBP; the disease is frontotemporal dementia.