On the other hand, it should be noted that patients with MM often present with anorexia and nausea/vomiting, which can lead to hypoglycemic events, particularly when medicated with high-risk oral antidiabetics, such as sulfonylureas, or high doses of basal insulin; basal therapy adjustments are recommended, particularly by changing sulfonylureas to metformin and/or glinides, as well as avoiding mixed insulins and favoring rescue with rapid insulin according to pre-prandial glycemic levels (8, 77). The gene discussed is INS; the disease is Anorexia.