Serum albumin (Alb) can not only maintain the plasma colloid osmotic pressure and reduce the extravasation of liquid into the intercellular matrix but also can be anti-inflammatory and can be an antioxidant and plays an important role in acute and chronic heart failure (HF), acute coronary syndrome (ACS), septic shock, nephrotic syndrome, cirrhosis, stroke, and malignant tumours [6–12]. This evidence concerns the gene ALB and congestive heart failure.