As illustrated in Figure 6a and b, EPHA3, MMP7, BIRC7, and ROS1 exhibited significant upregulation in the SEC61A1high (n = 95) compared to the SEC61A1low (n = 94) AML cohort, with |log2FC| > 2 and a P-value <0.05. This evidence concerns the gene BIRC7 and acute myeloid leukemia.