Except for CD2AP, MYH9, MYH10, and FLNB, disulfidptosis-related genes including CAPZB, PDLIM1, MYL6, FLNB, IQGAP1, CD2AP, TLN1, DSTN, and ACTB were downregulated in PRAD cancer tissues. The gene discussed is DSTN; the disease is cancer.