The results of this study showed that FLNA, IQGAP1, MYH10, TLN1, PDLIM1, INF2, CAPZB, ACTN4, DSTN, and MYH9 were significantly positively associated with DC cell infiltration in specific cancers, with a significant negative correlation between DC cells in DSTN and THCA. This evidence concerns the gene PDLIM1 and cancer.