In this study, increased expression of PDLIM1, INF2, ACTB, CAPZB, MYL6, FLNA, TLN1, and CA2AP was significantly correlated with increased NK cell infiltration in specific cancers; notably, CD2AP levels showed a significant negative correlation with NK cell infiltration in PRAD. The gene discussed is ACTB; the disease is prostate adenocarcinoma.