EDNRA and central nervous system cancer: It is highly expressed in gliomas [32,33], CRC [34], PRAD [35], THCA [36], BRCA [27], PAAD [33,37,38], ESCA [39], LIHC [33], HNSC [40], and other tumor tissues; it promotes the EMT, tumor cell proliferation and migration, and invasion through Wnt/β-linked protein signaling, NF-κB, endothelin-1 receptor signaling, MAPK, and other pathways, and it inhibits ECM degradation [41] and apoptosis [27].