Emerging evidence showed that COMP also promoted breast cancer stem cell induction by activating Jagged1-Notch3 signaling (Papadakos et al., 2019), and accelerated breast cancer metastasis by modulating the metabolic process and metalloprotease-9 (MMP-9) secretion (Englund et al., 2016). The gene discussed is NOTCH3; the disease is breast cancer.