TGFB1 and hepatocellular carcinoma: Overexpression of miR-199b-5p inhibited TGF-b1-induced Akt phosphorylation, and inhibition of PI3K/Akt pathway blocked TGF-b1-induced N-cadherin expression to promote cell aggregation, inhibiting Cell migration and invasion in HCC cells and inhibition of tumor metastasis in nude mouse (Zhou et al., 2017).