miR-425-5p targets both SCAI and PTEN and promotes HCC cell invasion and metastasis through SCAI-mediated dysregulation of integrin β1-Fak/Src-RhoA/CDC42, PTEN-AKT, and TIMP2-MMP2/MMP9 signaling, clinical experimental results also showed that high expression of miR-425-5p also predicted poor prognosis and low long-term survival after surgery (Fang et al., 2017). This evidence concerns the gene AKT1 and hepatocellular carcinoma.