High levels of miR-197 expression promote EMT and invasion of HCC cells in vitro and in vivo, and mechanistically, miR-197 directly targets Wnt/β-catenin signaling negative regulators Axin-2, Naked cuticle 1 (NKD1) and Dickkopf-related protein 2 (DKK2) thereby increasing the activity of TCF/LEF and accelerating the nuclear accumulation of β-catenin (Hu et al., 2018). This evidence concerns the gene DKK2 and hepatocellular carcinoma.