In addition, previous study shows that miR-492, miR-519a, miR-21, miR-93, and other regulatory factors are involved in the PTEN/AKT/GSK signaling pathway, and these regulatory factors promote cell proliferation and invasion by promoting cell proliferation and invasion to aggravate the EMT process of hepatoma cells (Bao et al., 2013; Jiang J et al., 2014; Ohta et al., 2015; Tu et al., 2016). Here, PTEN is linked to hepatocellular carcinoma.