In addition, another team found that exosomal miR-21 and miR-10b induced by the acidic microenvironment of HCC promoted the proliferation and metastasis of cancer cells, and also triggered the activation of HIF-1α and HIF-2α to exacerbate the metastasis of HCC cells and ectopic colonization. This evidence concerns the gene HIF1A and hepatocellular carcinoma.