The EMT inhibitory effect of miR-451 on hepatoma cells is mainly reflected in that miR-451 targets the oncogene c-Myc to inhibit cell proliferation and reduces the activation of Erk1/2 signaling to control EMT-related marker proteins including E-cadherin and its MMPs family member (Huang JY et al., 2015). Here, MAPK3 is linked to hepatocellular carcinoma.