In addition, miR-15b-5p, miR-421, miR-1303, miR-221-3p, and miR-486-5p are involved in TGF-β/BMP signaling pathway, angiogenesis, autophagy, and inflammation, promoting HCC malignant development and EMT transformation (Critelli et al., 2017). This evidence concerns the gene TGFB1 and hepatocellular carcinoma.