FOXP3 and systemic lupus erythematosus: In addition, Stadtlober et al. included 196 patients with SLE and 157 healthy controls and evaluated the association between rs2232365G/A and rs3761548C/A FOXP3 variants and SLE susceptibility and the SLE disease activity index; they noted that the G/C haplotype plays a protective role against SLE, whereas allele A in the above two variants may favor disease activity and autoimmunity.