Our previous study showed that HESS was more effective than glibenclamide in lowering the body oxidative state and pro-inflammatory cytokines such as hs-CRP and TNF-α, and raising antioxidant capacity.11 In this study, we assessed the possible effects of HESS on angiogenesis as the most critical process in the occurrence of diabetes complications and compared the results with the effects of glibenclamide. The gene discussed is TNF; the disease is diabetes mellitus.