VEGFA and neoplasm: Such a correlation has also been reported in tumor studies, such as the report by Barbieri et al who claimed that VEGF can induce the production of eNOS and NO.28 However it is northworthy to say, NO shows an opposite and double-behavior in physiological condition: As a protective agent against ROS, it scavenges free radicals and as an oxidizing agent, it produces ONOO-.