The PI3K/AKT/mTOR pathway is of paramount significance in various cancers, such as renal cancer (Badoiu et al., 2023), gastric cancer (Fattahi et al., 2020), ovarian cancer (Ediriweera et al., 2019), non-small-cell lung cancer (Yip, 2015), acute myeloid leukemia (Nepstad et al., 2020), and endometrial cancer (Yunyun Li et al., 2016). The gene discussed is MTOR; the disease is cancer.