In addition, the relative mRNA expression of bile salt export pump (BSEP) and sodium taurocholate cotransporting polypeptide (NTCP) were significantly increased in the CH group, and there were no significant changes in the FXR and sterol 27-hydroxylase (CYP27A1) among the three groups (Fig. 5F). This evidence concerns the gene CYP27A1 and cyclic hematopoiesis.