APOC3 and Seckel syndrome: Three of these variants had maximum AF > 4% (found in the PAR subpopulation): (1) a missense variant (rs373804633; category 3; c.298C>T; p.Arg100Trp) in RBBP8, a gene associated with Seckel syndrome (MIM# 606744), (2) loss-of-function variant in APOC3 (rs76353203; category 3; c.109C>T: p.Arg37* associated with apolipoprotein C-III deficiency (MIM# 614028) [47] that characterized by low levels of triglycerides (discussed in details below), and (3) missense variant in SLC2A10 (rs80358230; category 2; c.243C>G; p.Ser81Arg) which is associated with arterial tortuosity syndrome (MIM# 208050) [48].