The highest differences in terms of allele frequency is observed in the PAR subpopulation, where previously known founder variants have also been observed, including the variant in DCAF17 (rs797045038; category 1; c.436delC; p.Ala147fs), associated with Woodhouse-Sakati syndrome (MIM# 241080) [49], and CFTR (rs75389940; category 1; I1234V) which is the most frequently reported cystic fibrosis (MIM# 219700) variant in patients with Arab descent [50], with a corresponding PAR allele frequency of 1.7%. The gene discussed is CFTR; the disease is cystic fibrosis.