Notably, none of these variants was annotated as pathogenic/likely pathogenic in ClinVar, while one was annotated as “DM” in HGMD, a missense variant in FGG (rs202132393; c.124G>A: p.Gly42Ser) reported in HGMD to cause congenital afibrinogenemia. This evidence concerns the gene FGG and complement factor I deficiency.