SALL4 is excessively expressed in various malignant tumors, such as esophageal cancer (He et al. 2016), gastric cancer (Wang et al. 2021a; Yang et al. 2021a; Shao et al. 2020), colorectal cancer (Ardalan Khales et al. 2015), hepatocellular carcinoma (HCC) (Yong et al. 2013), breast cancer (Dirican and Akkiprik 2016; Yang et al. 2022), lung cancer (Kobayashi et al. 2011; Li et al. 2020) and acute myeloid leukemia (AML) (Wang et al. 2016). The gene discussed is SALL4; the disease is esophageal cancer.