This review shows that SALL4 participates not only in the growth, anti-apoptosis, metastasis, and invasion of these cancers but also in drug resistance (Cheng et al. 2015a), EMT (Zhang et al. 2018), OXPHOS (Tan et al. 2019), DNA methylation (Yang et al. 2012) and angiogenesis (Abouelnazar et al. 2023a), in some cases. The gene discussed is SALL4; the disease is cancer.