SALL4 and esophageal squamous cell carcinoma: SALL4 is overexpressed in ESCC tissues (He et al. 2016; Zargari et al. 2020; Yang et al. 2007; Forghanifard et al. 2014), which indicates its involvement in ESCC progression and reveals the underlying function of SALL4 as a predictor in the early diagnosis and therapy of ESCC (Fig. 1).