Overall, there were statistically significant differences between non-CKD and CKD participants in terms of sex, age, race, educational attainment, BMI, smoking status, CVD, DM, hypertension, Klotho, TC, TG, WBC, Neu, Mono, SII, NLR, MLR, SIRI, PIV, eGFR, serum creatinine, uric acid and serum urea nitrogen (all P < 0.05). This evidence concerns the gene KL and Hypertension.