KL and chronic kidney disease: The continuous analysis showed that the effect of Klotho on all-cause mortality in the CKD population was HR 0.933 (95% CI 0.891, 0.976) with P = 0.003 in the unadjusted model and HR 0.942 (95% CI 0.890, 0.997) with P = 0.039 in the adjusted model.