IGF1R and type 2 diabetes mellitus: Considering that one previous study has reported that Klotho could improve hepatic lipid metabolism abnormalities in type 2 diabetic mice by directly interacting with the type 1 insulin-like growth factor receptor (IGF1R) to upregulate PPARA expression [14], we have more reasons to believe that Klotho positively regulates the lipid metabolism in CKD.