We further analyzed the relationship between glomerular and tubulointerstitial KL expression and eGFR or BUN in CKD by Spearman correlation analysis, respectively, and found that both glomerular and tubulointerstitial KL expressions in CKD were positively correlated with eGFR (R = 0.3832 and 0.5413, all P < 0.0001) (Fig. 1I, J). This evidence concerns the gene KL and chronic kidney disease.