Clinical studies have reported that various plasma cytokines and chemokines, such as IL1α, IL1β, IL6, IL10, IL16, IL17, IL23, IL33, IFNα, TNFα, CCL2, CCL3, CCL5, CCL20, CXCL2, CXCL3, CXCL10, and CXCL13, were increased in patients with COVID-19. The gene discussed is IL16; the disease is COVID-19.