Similar to H151 treatment, the microglia in STING-KO mice engulfed less presynaptic and post-synaptic elements (SYP: F(2, 141) = 48.38, P < 0.0001, Fig. 6C; PSD95: F(2, 77) = 27.44, P < 0.0001, Fig. 6D) after stroke, accompanied by increased synaptic density around the infarcted region (F(2, 25) = 16.31, P < 0.0001, Fig. 6B, E). Here, DLG4 is linked to stroke disorder.