For example, the released mtDNA induced by ischemic stroke has been proven to contribute to microglia polarization, and the usage of STING inhibitor C176 could promote microglia phenotype transition from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype, which further contributes to infarction volume reduction and motor and cognitive function recovery [19, 22]. This evidence concerns the gene STING1 and ischemic stroke.