TNF and Stroke: We also evaluated the effects of H151 on inflammatory molecules after stroke and found that STING inhibition could significantly reduce the mRNA levels of Nlrp3 (F(3, 18) = 21.20, P < 0.0001, Fig. 4F), Caspase 1 (F(3, 17) = 7.969, P = 0.0016, Fig. 4G), Il1β (F(3, 18) = 14.32, P < 0.0001, Fig. 4H), and Tnfα (F(3, 17) = 21.93, P < 0.0001, Fig. 4I).