Similarly, IFNβ expression level was also suppressed by H151 (F(3, 19) = 16.10, P < 0.0001, Fig. 2C), accompanied by a reduction in the mRNA levels of interferon-stimulated genes (Oasl2, Isg15, Ifit3) after stroke (Oasl2: F(3, 18) = 10.13, P = 0.0004; Isg15: F(3, 17) = 7.613, P = 0.0019; Ifit3: F(3, 17) = 6.534, P = 0.0039, Fig. 2D). Here, ISG15 is linked to stroke disorder.