Patients with BBS2, BBS7, and BBS9 gene variants had more severe visual symptoms and multiple vision problems, such as night blindness, photophobia, decreased vision loss, narrow vision, and nystagmus, suggesting that the function of the BBSome complex is partially independent of chaperones, which is prominent in the development of the retinal dystrophy. This evidence concerns the gene BBS2 and Retinal dystrophy.