In contrast, miR-155-5p promotes the progression of CRC by targeting the negative regulator suppressor of cytokine signaling 1 (SOCS1) and SH2 domain-containing inositol 5-phosphatase 1 (SHIP1) to enhance Toll-like receptor 4 polypeptide (TLR4) signaling; TLR4 activation induces miR-155-5p expression through transcriptional and post-transcriptional mechanisms [35]. Here, SOCS1 is linked to colorectal carcinoma.