PTEN and colorectal carcinoma: miR-135-5p is a cancer-promoting factor, and the high expression of miR-135-5p in patients with CRC is associated with adenomatous polyposis coli (APC) gene deletion, phosphatase, and tensin homolog (PTEN)/PI3K pathway dysregulation, and altered expression levels of circulating RNA circNOL10 [33, 34].