CTCF and non-small cell lung carcinoma: In addition, the observed increase in histone acetylation levels in human non-small cell lung cancer cells and human lymphoma cells can promote the expression of DNMT1, cause hypermethylation at the ICR binding site of CTCF-H19/IGF2, and reduce the occupancy of CTCF at the ICR of H19/IGF2 [173].