The expression of Brg1 in both TAC and isoprenaline-induced cardiac hypertrophy models was upregulated, demonstrating that hypertrophy signaling promotes the enrichment of Brg1 to regulate the transcriptional activator of the pro-hypertrophy gene, GATA4, and promote cardiac hypertrophy [57]. This evidence concerns the gene GATA4 and cardiac hypertrophy.