The lncRNA ZFAS1 has been identified to have apparent differential expression in myocardial infarction, which binds to the promoter of Notch1 and recruits DNMT3B to the promoter of Notch1, triggering Notch1 methylation and inhibiting the expression of Notch1, hindering cardiac repair and cardioprotective function [40, 41]. This evidence concerns the gene NOTCH1 and myocardial infarction.