As expected, compared with HF rats housed in a normal diurnal cycle (LD group), suppression of Bmal1 expression via injection of LV-Bmal1 shRNA (LV-Bmal1 shRNA group) led to a suppression in the mRNA and protein levels of Clock and Bmal1, while upregulating Rev-erbα expression (P < 0.05). The gene discussed is CLOCK; the disease is hydrops fetalis.