CASP1 and neurodegenerative disease: The elucidation of pyroptosis mechanisms has drawn attention to the connection between inflammation associated with GSDMD and the pathogenesis of neurodegenerative diseases.450,451 Notable neurodegenerative diseases encompass Alzheimer’s disease (AD) and Parkinson’s disease (PD).449 Pyroptosis is implicated in the initiation of amyloid β-protein (Aβ) aggregation and neuronal death in AD, contributing to the onset and advancement of this disorder.452 Caspase-1 inhibition by administration of VX-765 attenuates cognitive dysfunction and neuroinflammation in an animal model.