GSDMC and helminthiasis: However, Zhao et al. offered a contrasting perspective, suggesting that although GSDMC gene expression was highly increased in IECs following worm infection, it primarily functioned through a pyroptosis-independent pathway.171 They proposed that STAT6 O-GlcNAcylation regulated membrane pore formation by GSDMC-NT in IECs, which promoted IL-33 unconventional secretion as an alarm response, thereby potentiating the development of type 2 immunity.