PARP1 and cancer: Knockdown of GSDMD inhibits cancer growth in vivo and in vitro, concurrent with the activation of caspase-3 and PARP cleavage, and enhances cancer cell death via the mitochondrial intrinsic apoptotic pathway.408 Furthermore, high GSDMD expression in lung adenocarcinoma (LUAD) implies a poor prognosis relative to lung squamous cell carcinoma (LUSC).