GSDMD and systemic lupus erythematosus: DSF treatment potently inhibits serum from SLE patients-induced THP-1 pyroptosis.506 DSF mitigates elevated levels of serum IL-1β and GSDMD-mediated glomerular macrophage pyroptosis as well as the infiltration of inflammatory cells, proliferation of tethered cells, and structural disorders of renal tubules in pristane-induced lupus (PIL) mice.506 In addition, neutrophil NET promotes the development of SLE.