The researchers did not detect infected neutrophils in COVID-19 patients, suggesting that neutrophil infection may not be a central mechanism in pathogenesis, although NETosis induced by GSDMD may be an essential driver.382 Conversely, Silva et al. reported a significant role for GSDMD-dependent NETosis in the immunopathology of COVID-19, proposing that interventions targeting GSDMD could represent a novel strategy for enhancing therapeutic approaches to the disease.383 They observed that serum NET and GSDMD levels were elevated and positively correlated with severe cases of COVID-19. The gene discussed is GSDMD; the disease is COVID-19.