Non-alcoholic fatty liver disease (NAFLD) represents a widespread chronic liver disorder, frequently coexisting with metabolic syndrome, including hyperlipidemia, obesity, and type 2 diabetes mellitus (T2DM).460–462 Several reports have suggested that NLRP3 inflammasome plays a role in the pathogenesis of NAFLD.69,463–465 GSDMD may also contribute to its progression. This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatotic liver disease.