Various drugs for cancer treatment act in part through caspase-3/GSDME-mediated tumor cell pyroptosis, including triptolide,414 mesothelin-targeting antibody-drug conjugate,415 apoptin,416 platinum-based drugs,417,418 tetraarsenic hexoxide,419 and alantolactone.420 GSDME knockout or knockdown may mitigate the anti-tumor potency of these agents. The gene discussed is CASP3; the disease is cancer.