In pancreatic ductal adenocarcinoma (PDAC), cells deploy GSDME to enhance mucin 1 and mucin 13 secretion, effectively establishing a protective barrier against the digestion enzyme chymotrypsin.422 This regulatory function of GSDME is distinct from its pyroptosis-inducing function, instead involving a regulatory mechanism where it interacts with and facilitates the nuclear translocation of the transcription factor Y-box-binding protein 1 (YBX1), which then directly enhances the expression of mucins. Here, GSDME is linked to pancreatic ductal adenocarcinoma.