GSDMD and Alzheimer disease: Encountering GSDMD-NT expression in microglia and astrocytes in the immediate vicinity of Aβ deposits implies a potential influence of Aβ on the processing of GSDMD.456 These findings suggest that inflammasomes and GSDMD are involved in neuroinflammation in AD, but the roles and mechanisms of GSDMD in various cell types in AD remain unclear due to its complex pathogenesis.