DSF treatment inhibits the progression of EAE and greatly reduces clinical and histopathological scores.502 DMF impedes the development of EAE and reduces neuropathology and demyelination.46 C202-2729, a recently identified GSDMD inhibitor, significantly inhibits the aggregation of immune cells and demyelination within the spinal cord of EAE.503 These investigations corroborate the concept that GSDMD-induced pyroptosis serves as a determinant in the pathogenesis of MS. Here, GSDMD is linked to myeloid sarcoma.