GSDMD and hepatocellular carcinoma: GSDMD−/− or WT mice treated with a combination of the GSDMD inhibitor DMF and an anti-PD-1 antibody showed reduced liver tumors and decreased PD-L1 expression.409 Consequently, the authors proposed that an approach encompassing both anti-PD-1 and GSDMD inhibitors could be effective in treating HCC with upregulated GSDMD.