GSDME−/− mice results in a notable reduction in lung inflammation and a substantial increase in survival rates when exposed to a lethal dose of the H7N9 virus.393 Recently, activation of GSDME has also been found to be associated with Zika virus (ZIKV), foot-and-mouth disease virus (FMDV), and oncolytic parapoxvirus ovis (ORFV) infections. The gene discussed is GSDME; the disease is infection.