Podocytes are an important target of injury in the early stages of DN, with their degeneration and loss being intimately linked to the manifestation of proteinuria.477 In diabetic mice, renal podocytes exhibit markedly heightened expression levels of caspase-11 and GSDMD-NT, concomitant with an amplified release of IL-1β and IL-18. The gene discussed is GSDMD; the disease is liver dysplastic nodule.