The role played by GSDMs in cancer varies according to the environment, varying among different GSDM isoforms and cancer entities, underscoring the complex interplay between inflammation and tumourigenesis, cell proliferation, as well as anti-tumor immune responses.427,428 Further understanding of the functions of GSDMs, both pyroptosis-dependent and pyroptosis-independent, as well as its role in tumor immune checkpoints such as PD-1/PD-L1, may potentially impact the combination therapy strategies for tumor. The gene discussed is CD274; the disease is cancer.