Other GSDMs have been shown to be potentially associated with a multitude of cancers.411,412 Analyses of multiple bioinformatics databases demonstrate the involvement of GSDMs in HCC and clear cell renal cell carcinoma (ccRCC), with increased expression of GSDME correlating significantly with reduced overall survival in HCC and ccRCC patients.411,412 Studies have highlighted the engagement of GSDME in the pyroptotic demise of melanoma cells. The gene discussed is GSDME; the disease is hepatocellular carcinoma.