Xu et al. elucidated the critical role of GSDMD in the development of non-alcoholic steatohepatitis (NASH) by mediating lipogenesis and NF-κB signaling pathway.466 GSDMD-NT expression is positively associated with the activity score and fibrosis in NAFLD. Here, NFKB1 is linked to metabolic dysfunction-associated steatohepatitis.