GSDME and cancer: Inhibition of eukaryotic elongation factor-2 kinase (eEF-2K) can inhibit autophagy and promote GSDME-mediated pyroptosis, which in turn modulates the susceptibility of melanoma cells to doxorubicin.413 ROS in the presence of iron have been implicated in triggering pyroptosis in melanoma cells via the Tom20-Bax-caspase-GSDME pathway.187 Inducing tumor pyroptosis to promote anti-tumor immunity is a potential cancer treatment strategy.