After nuclear translocation, GSDMD engages in a complex with poly (ADP-ribose) polymerase 1 (PARP-1), significantly suppressing the function of PARP-1 on DNA damage repair, thereby functioning as a tumor suppressor to enhance apoptosis in cancer cells.407 They concluded that the subcellular distribution of GSDMD could potentially help guide the treatment of colorectal cancer. This evidence concerns the gene GSDMD and neoplasm.