GZMB and neoplasm: These findings suggest that GSDMD functions as a suppressor of GC cell proliferation.405 Xi et al. demonstrated that GSDMD facilitates the cytotoxic activity of T lymphocytes (CTLs) against cancer cells, primarily by delivering the contents of cytotoxic granules into the immune synapse established with the tumor cells.406 Elevated levels of GSDMD processing within CTLs, concomitant with the proximity of GSDMD to granzyme B, are detected in the perimeters of the immune synapse, and GSDMD knockdown decreases cytotoxicity of CTLs.