Pharmacological modulation of USP48 could represent a potent approach to trigger tumor cell pyroptosis.307 Similarly, OTUD4 deubiquitinates and stabilizes GSDME to enhance the sensitivity of nasopharyngeal carcinoma to radiotherapy by promoting pyroptosis.306 These insights underscore the critical function of pyroptosis in the body’s offensive against tumors. This evidence concerns the gene OTUD4 and neoplasm.