GSDMD and Sepsis: GSDMD is a critical regulator of pro-inflammatory cytokine secretion by immune cells, and recent evidence suggests a pivotal modulatory role for GSDMD in the pathogenesis of sepsis.241,342 Although various sensors and mediators activate pyroptosis, the pore-forming activity of GSDMD-NT emerges as a compelling therapeutic target, as it is a universal terminal step required for pyroptosis and the secretion of pro-inflammatory cytokines in response to pathogenic or danger-induced signals.