The knockdown of Sp1 can reduce cell pyroptosis induced by chemotherapeutic drugs.196 GSDME also emerge as a potential tumor suppressor,197 serving as a transcriptional target of p53 that is frequently epigenetically silenced through methylation in various malignancies.198–200 The absence of GSDME has been shown to compromise the efficacy of certain chemotherapeutic agents.33,201. The gene discussed is GSDME; the disease is neoplasm.