TNFSF11 and osteoporosis: Studies have shown a pathophysiological relationship between osteoporosis and vascular calcification, which involves the pathogenesis of bone morphogenetic protein, RANKL‐RANK‐OPG pathway, wnt signaling pathway, matrix gla protein, and vitamin K.6, 7Low BMD is not only a risk factor for osteoporosis, fracture, and death in the general population,8 but it also predicts coronary artery disease progression better than traditional risk factors such as hyperlipidemia and smoking.9