Thus, inappropriate AVP release is considered to be present when Ou>Ou,min or Ou>100 mOsmol/kg in the context of hyponatremia, since urine leaving Henle's loop and before entering the collecting duct is diluted to its minimum osmolality of approximately 100 mOsmol/kg (although some inter‐individual variation exists) (Hall & Guyton, 2016; Mount, 2018; Voets et al., 2021). The gene discussed is AVP; the disease is Hyponatremia.