We have previously demonstrated that HDL-mediated protection of macrophages against cell death involves S1PR1 (30) and SR-B1 (6), and we and others have reported that KO of either SR-B1 in bone marrow-derived cells (48, 65) or S1PR1 in myeloid cells (30), both of which include macrophages, results in increased cell death in atherosclerotic plaques and increased atherosclerosis development. The gene discussed is S1PR1; the disease is atherosclerosis.