SCARB1 and atherosclerosis: Similarly, genetic inactivation of either Sr-b1 or Pdzk1 in bone marrow-derived cells increases atherosclerosis in mice, and knockout of either S1pr1, Sr-b1, or Pdzk1 in bone marrow-derived/myeloid cells increases apoptosis and necrotic core development within atherosclerotic plaques (5, 30, 48), consistent with the possibility that these three factors participate in the same pathway.