In an orthotopic murine model of pancreatic ductal adenocarcinoma, intratumoral injection of the lymphoid chemokine CXCL13/CCL21 induced TLS formation and improved tumor response to systemic chemotherapy with gemcitabine, which was associated with TLS-associated B cell-mediated DC maturation [68]. The gene discussed is CXCL13; the disease is neoplasm.