In addition, in the state of cell energy stress, AMPK is stimulated resulting in inhibition of mTOR by phosphorylating directly and phosphorylating TSC2 at Ser1387 indirectly [11, 12] More importantly, over-expression of mTOR is often found in tumors, such as pituitary adenomas and penile squamous cell carcinoma [13, 14]. The gene discussed is MTOR; the disease is squamous cell carcinoma of penis.