PTPRC and Parkinson disease: After the long-term and continuous duration of immunosuppression, the immune-responsive cells were significantly depleted from 4 months p.t. to 8 months p.t. Until 12 months p.t., microglia nearly declined to normal brain-resident levels (Fig. 1), and lymphocytes were almost to extinction (Fig. 2), consistent with previous observation (Kikuchi et al. 2017) that few or no CD45+ lymphocytes infiltrated into human iPS-derived grafts at 12 months p.t. in PD cynomolgus monkeys with long-term Tacrolimus (also a calcineurin inhibitor, CNI) treatment.