CD74 and cancer: CD74 mRNA levels were significantly elevated in 21 cancers (BRCA, CESC, CHOL, COAD, DLBC, ESCA, GBM, HNSC, KIRC, LAML, LGG, LIHC, OV, PAAD, READ, SKCM, STAD, TGCT, THCA, THYM, and UCEC) and reduced in ACC, LUAD, LUSC, and UCS (Fig. 2A).