Among the significant pleiotropic associations of FECD risk alleles are a protective association with open-angle glaucoma at SSBP3, risk-increasing associations with benign colon neoplasms at laminin genes LAMA5 and LAMC1, and an association with increased heart rate at LAMB1, which is replicated in the UK Biobank (P = 2.0 × 10−8)57. Here, LAMC1 is linked to benign colon neoplasm.