Prior studies have found elevated levels of CUB domain-containing protein 1 (CDCP1), Monocyte Chemotactic Protein 3 (MCP-3), IL-13, periostin, IL-31, IL-6, caspase 8, β-endorphin, and autotaxin in the blood of PN patients5–7,23–25. This evidence concerns the gene IL31 and poikiloderma with neutropenia.