Therefore, to investigate the role of GADD45g silencing in the pathogenesis of myeloid malignancies, we generated hematopoietic-specific heterozygous (Gadd45g+/−) and homozygous Gadd45g knockout mice (Gadd45g−/−) by crossing Gadd45gflox/flox mice with the Vav-Cre mice (Supplementary Fig. 3a, b). The gene discussed is GADD45G; the disease is myeloid neoplasm.