To explore the contribution of histone modifications to the reduced expression of GADD45g in MPNs, we analyzed gene expression profilings of CD34+ BMMCs/PBMCs from MPN patients and found that GADD45g showed a marked inverse correlation with HDAC1 and HDAC2 expression (Fig. 10k–l). Here, HDAC1 is linked to myeloproliferative disorder.