Notably, de la Harpe et al. demonstrated that CBD induced ER stress response and the protective role of CBD in upregulation of unfolded protein response (URP) in breast cancer cell lines may relate to its activation of transient receptor protein vanilloid receptor 1 (TRPV1) channels and an associated increase in reactive oxygen species accumulation within the cell (de la Harpe et al. 2022). Here, TRPV1 is linked to breast cancer.