Indeed, knockdown of Linc01056 in HCC cells resulted in transcriptional activation of PPARα-specific target genes, including EHHADH, ACAA1 and ACOX1 (Fig. S6a) and resulted in nuclear localization of PPARα (Fig. S6b), confirming the transcriptional activation of PPARα. This evidence concerns the gene EHHADH and hepatocellular carcinoma.