Indeed, knockdown of Linc01056 in HCC cells resulted in transcriptional activation of PPARα-specific target genes, including EHHADH, ACAA1 and ACOX1 (Fig. S6a) and resulted in nuclear localization of PPARα (Fig. S6b), confirming the transcriptional activation of PPARα. Here, ACAA1 is linked to hepatocellular carcinoma.